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Mechanism of Action: The NNMT-NAD+ Axis The primary research value of 5-Amino-1MQ lies in its ability to modulate the nicotinamide metabolic pathway

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It provides a logical explanation for the development of dual targeting drugs such as MM-131 a bispecific anti-MET/EpCAM mAb [108] and also further drug discoveries targeting concurrently all three c-Met, EpCAm and Wnt pathway simultaneously to overcome both innate and acquired resistance to tyrosin kinase inhibitors (TKIs)