aafp glp 1 Cardiovascular Protection with a Long-Acting GLP-1 Receptor Agonist Liraglutide: An Experimental Update Prescribing GLP-1 Agonists for Weight

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Multi-country, multi-center long-term cardiovascular outcome trials (CVOTs) confirmed that GLP-1RAs decrease cardiovascular mortality and provide cardiovascular benefits to reduce the incidence of MI or non-fatal stroke [3]

Some patients may achieve adequate glycemic control or weight loss at this dose level, particularly those with mild metabolic dysfunction or those who are particularly sensitive to the medications effects

doi: 10.1001/jama.2018.14854 13

the published abstract describes this as a safety signal affecting a limited number of patients without a documented breakdown of exact case counts