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early initiation of DMARD therapy is essential if patients with RA are to achieve remission and to limit joint damage (13), whereas DMARD therapy is not recommended for patients with OA (14)

doi: 10.1007/s00330-023-09972-2 89 WangJ-LPengLLiZ-MYangF

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-arrestins have been shown to function as critical adaptors for agonist-induced endocytosis of GPCRs [56,57], and as important adaptors for agonist-induced ubiquitination of GPCRs [58,59], and scaffold MAPK cascades such as ERK1/2 and JNK3 within endosomes [60]

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