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Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance
The common adverse effects include mild, transient headaches, and skin eruptions ranging from mild to severe drug reactions such as fatal StevensJohnson syndrome and toxic epidermal necrolysis, kidney and liver dysfunction, thyroid dysfunction, severe abdominal pain, and fatal complications such as air embolism or sepsis due to incorrect method of IV administration.[] TOPICAL FORMULATIONS Topical formulations of glutathione are also available in the form of cream, facewash, soap, and lotion
