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One possibility is that amyloid precursor protein (APP) binds to GLP-1 as a G-protein-coupled receptor, resulting in reduced APP synthesis.183 GLP-1 RA reduces tau phosphorylation not only in the AD model, but also in diabetes.32,33,184,185 However, the mechanism by which GLP-1 RA reduces tau hyperphosphorylation may be complex

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A., Millanvoye-Van Brussel, E

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