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For the assay, all mice were anesthetized using isoflurane

Antioxidant and pro-oxidant effects of polyphenolic compounds and structure-activity relationship evidence

This review examines dysregulation of the KP in MDD, emphasizing KP metabolites particularly quinolinic acid and kynurenic acid as biomarkers and mediators of excitotoxicity, neuroinflammation, and oxidative stress, and discusses the therapeutic efficacy of antidepressants that modulate this pathway

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These findings suggest that AS-IV holds potential as an adjunctive agent in anti-tumor therapies, offering protection against the cardiac side effects, such as arrhythmia, that are commonly associated with SU treatment