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A total of 45 trials were included in the meta-analysis

35 Notably, this protective effect appears to be dependent on the duration of treatment, with only a GLP-1RA treatment period exceeding 52 weeks being associated with decreased fracture risk

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Tirzepatide is administered as a once-weekly subcutaneous injection with dose titration starting at 2.5 mg and increasing every 4 weeks through 5 mg, 7.5 mg, 10 mg, 12.5 mg, to a maximum of 15 mg as tolerated