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Washington, D.C: National Academy Press

There is no specific age that is a contraindication, but GHK-Cu should not be used in children or adolescents as its effects on a developing body are not studied

(PubMed) Abel MH, Brandlistuen RE, Caspersen IH, et al

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Furthermore, catalpol can inhibit the ubiquitination and degradation of PTEN, block the NF-B and AKT signaling pathways, and prevent the differentiation of bone marrow-derived macrophages (BMMs) and RAW264.7 cells induced by receptor activator of nuclear factor kappa-B ligand (RANKL) into osteoclasts