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It could produce a GSH-activity-related fluorescence signal via the fluorescence resonance energy transfer, due to the fluorophore (FAM) relatively far away from the quencher (BHQ)
The researchers notably found that epithalamin not only produces direct antioxidant effects, but also stimulates the expression of antioxidant enzymes like superoxide dismutase and ceruloplasmin [10]
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Free Radical Biology and Medicine, 62, 1325
Drop back to the last tolerated dose and stay there for 6-8 weeks before attempting escalation again
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