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Notably, GIP is secreted by the enteroendocrine K-cells that are present in high density in the duodenum and upper jejunum, while GLP-1-producing cells of the intestine are mainly positioned in the distal parts of the gut [44]

Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies 4,5,6,7,8,9

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Always discuss supplementation with your GP, trial clinician, or registered dietitian before starting, as high-dose supplements can be harmful