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Patient voice, quality-of-life measures, and patient-reported outcomes are gaining importance alongside traditional clinical endpoints, reflecting a broader shift toward value-based healthcare

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Inhibitors of specific signaling pathways were also incorporated: Compound C, an AMPK inhibitor, and MK-2206, an Akt1/2 inhibitor, both applied for 24 hours to determine the involvement of these pathways in the protective actions of Humanin [1]

The correct method is the swirl method