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Patients should not discontinue tirzepatide without medical guidance, except in cases of suspected severe allergic reactions or pancreatitis, where holding the medication pending urgent evaluation is appropriate

There is also a concern about the possibility of estrogen-induced malignant transformation in residual endometriosis implants

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Researchers tracking biomarkers (fasting glucose, resting metabolic rate, nitrogen balance) can detect timing-specific metabolic shifts within 710 days