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SLC47A1 and SLC47A2-K are characterized by a Km for thiamine in micromolar range (102), supporting the physiological relevance of thiamine extrusion by these transporters (Figure 2A)

Unregulated glucose uptake results in excess reactive oxygen species production [23]

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A key finding was that the magnitude of semaglutides effects on several drinking outcomes appeared greater than is often seen with existing medications to reduce alcohol cravings, even though semaglutide was only administered at the lowest clinical doses