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Glx/tNAA and clinical measure correlations Exploratory analyses revealed a positive relationship between Block-7 Glx/tNAA and Peak Glx/tNAA change and day 1 TEPS-A change scores for the placebo condition ( r = 0.45, P = 0.026 and r = 0.51, P = 0.011) but not for the naltrexone condition ( r = 0.05, P = 0.808 and r = 0.02, P = 0.932)

This observation correlates well with the fact that malaria patients exhibit high levels of homocysteine in their plasma and it appears that efflux of accumulated homocysteine into the infected RBCs and subsequently to the plasma may be the cause underlying hyperhomocysteinemia in malaria patients

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