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NNMT excessively consumes the precursor (nicotinamide) required for NAD+ synthesis, essentially creating a leak in the NAD+ production pipeline, leading to accelerated NAD+ depletion

As clinical signs of cobalamin deficiency include chronic wasting or failure to thrive, malaise, and gastrointestinal signs such as diarrhea, serum cobalamin concentration should be measured in any dog with poor response to enzyme replacement therapy for EPI

doi: 10.1038/s41598-020-63909-5

[1] But those values don't consider your acute or long-term iron statustwo people of the same age and gender with different blood levels of ferritin, for example, should consume very different amounts of iron each day

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