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The rubber stopper keeps coring Coring happens when the needle punches through the rubber stopper instead of cleanly piercing it, depositing a tiny rubber fragment into the solution

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The greatest effects on gastric motility appear to occur during treatment initiation, dose escalation phases, and higher-dose maintenance therapy

Hyer, J

This decline correlates directly with the loss of regenerative capacity that comes with aging, which is part of why older individuals struggle more with skin elasticity after weight loss