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Yeungnam University Journal of Medicine , 36 (3), 183191

We concluded that the immobilized protein remained bound to the column after elution with low pH, allowing the reuse of the column for alternative uses, such as screening for other proteinprotein interactions using SPINK3 as the bait

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Application of MALDIMSI across diverse malignanciesincluding colorectal, lung, breast, liver, and brain tumorshas uncovered spatially organized metabolic gradients associated with hypoxia, immune infiltration, stromal composition, and therapeutic response, thereby providing mechanistic insights into regional immune suppression and functional divergence of immune cells within the TME (98, 99)