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However, the study did not include people who made lifestyle changes on their own, such as joining a gym or weight-loss programs

Similarly, obesity can lead to hormonal imbalances that may disrupt the timing of menstruation

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The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)

For optimal results, clinicians should consider individualized approaches, monitor for possible adverse effects, and ensure supplementation is integrated into a broader treatment plan grounded in evidence-based practice