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Intraperitoneal, but not intracerebroventricular, administration of INSL-5 dose-dependently increases food intake in mice, indicating the peptide may exert its orexigenic effect by acting on peripheral targets, rather than via the CNS (164)

Current evidence indicates that melanocortin-4 receptor (MC4R) activation serves as the primary driver of its sexual function effects, with additional contributions from MC3R and MC1R pathways

It is most accumulated in cardiac and skeletal muscles as it accounts for 0.1% of its dry matter

Neuroprotective effects could be especially important in treating neurodegenerative diseases such as Parkinson's disease or Alzheimer's disease