That difference comes from a single amino acid substitution
Who needs tighter monitoring
Bar-Sela G, Wollner M, Hammer L, Agbarya A, Dudnik E, Haim N
Glycyrrhizin inhibits the metabolism of diosbulbin B (Yang et al., 2024), promotes bile acid efflux by increasing the expression of Nrf2/Farnesoid X Receptor- Bile Salt Export Pump (FXR-BSEP)/Multidrug Resistance-Associated Protein (MRP)2/P-glycoprotein/UDP-glucuronosyltransferase 1A1(UGT1A1), modulates gut microbiota, alleviates inflammation and oxidative stress, and improves diosbulbin B-induced liver injury (Wang et al., 2025)
Topical tranexamic acid with microneedling versus microneedling alone in treatment of melasma: clinical, histopathologic, and immunohistochemical study