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doi: 10.1016/j.cmet.2009.08.001 38 LarraufiePMartin-GallausiauxCLapaqueNDoreJGribbleFMReimannFet al

Protein carbonylation in human diseases

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While body weight and metabolic phenotypes remain the primary endpoints, the outcome spectrum is progressively extending toward lipotoxic load [e.g., hepatic fat and visceral adipose tissue (VAT)], inflammatory/cardiometabolic risk markers, and reproductive outcomes with higher clinical decision-making value, such as menstruation, ovulation, and pregnancy

These strategies are aimed at promoting tissue repair, and preclinical and preliminary clinical evidence suggests they may improve measures of IC/BPS symptoms and bladder function