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The SOUL trial (2025), a large-scale, double-blind, placebo-controlled study, evaluated once-daily oral semaglutide in 9,650 patients with T2DM and established atherosclerotic cardiovascular disease, chronic kidney disease, or both

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If you are wondering how long semaglutide takes to work or whether appetite suppression is immediate , most people notice changes within days of the first injection, though weight loss takes weeks to become visible