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During these processes, GSH is converted into its oxidized form, glutathione disulfide (GSSG)

Excessively rapid detoxification symptoms may occur if toxic mobilization outpaces elimination capacity, particularly in individuals with significant heavy metal burdens or compromised detoxification capacity

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Similar abnormalities are seen in erythrocyte sedimentation rates (ESR) [372, 373], as well as in other conditions such as delayed cerebral ischemia following subarachnoid hemorrhage [374]