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Pre-treatment of rats with 120 g/kg DSIP 20 minutes prior to subjection to hypoxia completely inhibited these hypoxia-induced reductions in mitochondrial respiratory activity

Inflammatory mediators can cross the bloodbrain barrier, activating the microglia and leading to the release of neurotoxic factors with adverse effects on dopaminergic neurons [21]

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation