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These include some antibiotics, metformin (for diabetes), and stomach acid reducers like proton pump inhibitors (PPIs) or H2 blockers

The standard cut-off for screening for major depression is 10 or above [26]

The compounds research-only status reflects the absence of completed human clinical trials rather than a determination that it is inherently dangerous a distinction that is important for interpreting its regulatory position accurately

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The upregulated gene clusters are enriched in extracellular matrix components (collagens I and III, decorin, elastin), antioxidant defense systems (superoxide dismutase, glutathione-related enzymes), DNA repair pathways, and anti-inflammatory mediators including IL-10 and TGF-beta family members