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Mainly owing to its close association with the components of the metabolic syndrome, i.e., type 2 diabetes mellitus (T2DM), obesity, arterial hypertension and dyslipidemia, a change in the nomenclature of the disease to metabolic dysfunction-associated steatotic liver disease (MASLD) together with a change to the definition of the disease have been proposed [2]

Retatrutide is an investigational injectable medication under clinical development for the treatment of obesity and type 2 diabetes

Further clarity is required around the optimal timing of combination and sequential add-on therapy initiation

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