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These findings suggest that PK activators could be potential novel therapeutic options for management of other hereditary RBC disorders such as HS characterized by excess oxidative stress, perturbation of the glycolytic pathway, and/or relative PK deficiency

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The normality assumption of the data was examined with the ShapiroWilk test, and the homogeneity of group variances was checked with the Levene test

Hepatotoxicity indices were measured because, beside the kidneys, the liver is the chief organ in charge of carnitine production, justifying the rationale behind assessing both organs performance

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