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and (v) for female patients, no pregnancy/lactation

These include increasing muscle mass (1,49, 55,), reducing body fat (49, 50, 51), helping to maintain muscle mass during weight loss (51), suppressing appetite to aid fat loss, increasing metabolism (50), improving immune function, reducing blood pressure (52), reducing unhealthy blood fats (53), improving blood glucose levels in type 2 diabetics, and increasing the production of glutathione, the bodys master antioxidant (54)

Metformin: summaries of product characteristics

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones

The cardiovascular safety of retatrutide has not been established in a dedicated outcomes trial