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They also produce glucose-dependent insulinotropic peptide (GIP), which has an incretin effect like that of GLP-1, the motility hormones (motilin and serotonin), and other hormones such as secretin (SCT) and GLP-2, which regulate digestion and intestinal homeostasis [13]

Healthy beta cells secrete a burst of insulin into the portal circulation at the onset of glucose intake, with approximately 70% of the insulin cleared by the liver and not entering the systemic circulation, whereas subcutaneous insulin enters the systemic circulation with some delay and is removed relatively slowly

Instead, hair changes observed during treatment more likely reflect the physiological effects of rapid weight loss, including calorie restriction, nutritional changes, and physiological stress