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Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1

The pivotal early-efficacy readout in obesity came from a randomized, double-blind, placebo-controlled, dose-finding Phase 2 trial published in The Lancet Diabetes & Endocrinology (le Roux and colleagues), conducted across 43 centers in 12 countries and registered as NCT04667377

Intracellular reactive oxygen species mark and influence the megakaryocyte-erythrocyte progenitor fate of common myeloid progenitors

In the future, mutant strains with deletions of specific gene fragments, vaccines, or purified biomacromolecules could serve as essential alternatives in the prevention and treatment of invasive intestinal candidiasis

Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the toll-like receptor 4 (TLR4) promoter and increased TLR4 expression