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Naltrexone, an opioid receptor antagonist, is FDA-approved for alcohol use disorder and works by blocking the pleasurable effects of alcohol

Johns Wort can accelerate clearance and diminish efficacy, whereas inhibitors like ketoconazole, clarithromycin, certain protease inhibitors, or excessive grapefruit intake may elevate serum estradiol and increase adverse-event risk

Suppresses appetite and promotes a balanced diet

The most frequently observed adverse events are gastrointestinal in nature, which we have seen are typically transient and dose-dependent

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