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The effect of metformin therapy on luteinizing hormone receptor agonist-mediated stimulation of testosterone production and spermatogenesis in diabetic rats

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Mammalian target of rapamycin (mTOR) signaling inhibitor mTOR is a highly conserved serine/threonine kinase and is well known to be essential for the regulation of cell metabolism, growth, and proliferation ( H 17 and CD3 + CD4 CD8 double negative T, as well as, contraction of Tregs ( Administration of the mTOR inhibitor rapamycin, results in immediate inhibition of mTORC1 signaling and delayed inhibition of mTORC2 signaling

[DOI] [PubMed] [Google Scholar] 142.Bansal A., Simon M