SHANK3 mutations are likely to cause mitochondrial dysfunction in PMS because six mitochondrial genes, including NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6 ), cytochrome c oxidase assembly ( SCO2 ), tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase ( TRMU ), thymidine phosphorylase ( TYMP ), carnitine palmitoyltransferase 1B ( CPT1B ), and aconitase 2 ( ACO2 ), are adjacent to SHANK3 in the 22q13.3 region [339]
(ii) improvement in insulin sensitivity, where and indices improve through the combined effects of weight loss and adipose tissue redistribution (78)
These differences could influence the choice of peptide in formulations targeting specific wound healing applications
Then came bempedoic acid (Nilemdo) and Nustendi (its combination with ezetimibe)
Zimmet P, Alberti KGMM, Shaw J