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L., Liu, Q., Salisbury, J
Through its ferroxidase activity, FtMt prevents the accumulation of redox-active ferrous iron and restrains mitochondrial reactive oxygen species (mtROS) generation [82]
It has the ability to scavenge free radicals and chelate iron
Moreover, TNF- can promote glycolysis through the activation of the NF-B signaling pathway, supporting rapid tumor cell proliferation by inducing metabolic reprogramming in the tumor microenvironment [234, 237] and thereby enhancing the adaptive growth and metastatic capabilities of tumor cells
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