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Obesity, insulin resistance (IR), steroid hormones imbalance and intestinal microecological imbalance, deficiencies in vitamin D and selenium, as well as hyperhomocysteinemia (HHcy) can induce systematic imbalance between pro-inflammatory and anti-inflammatory cells and molecules

In the study by Razavi et al ., crocin, per se, did not affect systolic BP and heart rate [66]

Indeed, NRF2 was found constitutively active in intestinal stem cell (ISC) in , and KEAP1-mediated NRF2 repression was required for ISC proliferation

But could they actually work together in a synergistic way, ecreating the ideal state of being calm yet energized

Journal of Molecular Biology