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taking with food may help minimize this

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DSIP has a plasma half-life of only a few minutes due to rapid degradation by blood peptidasesyet behavioral effects in sleep normalization and HPA axis modulation persist for days to weeks after a single administration

I commonly use diindolylmethane (DIM) and sulforaphane from cruciferous vegetables to encourage healthy 2-hydroxylation of estrogen, calcium-D-glucarate to support glucuronidation, magnesium and methylated B vitamins for methylation, and glutathione to help neutralize reactive estrogen metabolites

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