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It encompasses the structural and functional aspects of the cellular surroundings, but also the presence of metabolites such as glucose, amino acids and lipids within the TME, as well as environmental factors such as hypoxia and acidity (81)

Trends Food Sci Technol 93:8193 Graton ME, Ferreira BH, Troiano JA, Potje SR, Vale GT, Nakamune AC, Tirapelli CR, Miller FJ, Ximenes VF, Antoniali C (2022) Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects

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On comparing, the results of therapeutic effect of both drugs on VAS from baseline to 8th and 12th weeks, it was found that the average score (mean standard deviation) with TA (right cheek) was significantly lesser when compared with glutathione (left cheek) [Table 2]