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In recent years, the scientific community has focused on two key endogenous molecules NAD (Nicotinamide Adenine Dinucleotide) and reduced glutathione (GSH) whose progressive depletion with age is now correlated with the main signs of cutaneous and systemic ageing. NAD: the anti-ageing metabolic powerhouse NAD is an essential coenzyme involved in hundreds of redox reactions and a fundamental substrate for sirtuins and PARPs, pro-longevity enzymes that regulate DNA repair and mitochondrial function

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein