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Clinical status of phytochemicals For decades now, it has been established that endothelial dysfunction and, ultimately, atherosclerosis are directly linked to the increase in oxidative stress that occurs during the progression of diabetic hyperglycemia

Rinella, M.E., Lazarus, J.V., Ratziu, V., et al

Additional Reported Adverse Effects Beyond gastroparesis and vision loss, patients have reported numerous other serious adverse effects that have led to FDA warning label updates as evidence accumulated

Topical use is best as a secondary support rather than a primary strategy

In response, sponsors are tightening criteria, shifting cost sharing, and even considering carve-outs