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In some patients, particular LEPR mutations that result in abnormal cleavage of the extracellular domain of LEPR (which then acts as a leptin binding protein), are associated with markedly elevated leptin levels (15)
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Most GI symptoms are temporary and peak during dose escalations
Of course, any time rapid weight loss is a side effect of a drug, interest (and demand) tend to spikeas does speculation about long-term risk factors and supply issues for patients treating chronic disease
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