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Maintenance every 23 months

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On the molecular level, caffeine (chemically known as 1,3,7-trimethylxanthine) is an alkaline, organic substance derived from xanthine a biologically important purine base found in many bodily tissues and fluids

Consequently, we show that several thiol-containing compounds, including dithiothreitol, N-acetyl-L-cysteine, and glutathione, perform a nucleophilic attack on the amoxicillin molecule that is followed by an internal rearrangement leading to amoxicillin diketopiperazine, a known amoxicillin metabolite with residual activity

Science 264 , 17721775 (1994)