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They demonstrated no significant elevations in IGF-1 levels and no significant changes in body composition parameters, but they did show improvements in a couple of muscle strength tests.11 Study three A separate 1997 study was more promising

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Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78