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So xanomeline, which is under investigation, targets the M1 and M4 subtypes of the muscarinic and acetylcholine receptors in the brain (Foster et al., 2021

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With the G-Trap, we measured Rac1GTP in peripheral blood monocytes (PBMC) and polymorphonuclear (PMN) cells from blood samples collected from 28 culture-positive patients and over 80 non-infected patients used as controls