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While increases in serum potassium levels were observed compared to placebo, the increase was significantly lower compared to spironolactone at all doses of finerenone

There was no consensus on the optimal timing of GLP-1 RA add-on therapy after initiating an SGLT2i, nor on the feasibility of initiating both therapies within a 4-week interval (referred to as simultaneous)

According to McMahon, "Some prebiotics contribute to GI issues like gas and bloating, so I prefer to dose them separately." Koenig, on the other hand, says that she's found synbiotics helpful for some of her clients

Plasma insulin was quantified using AlphaLISA Insulin kit (PerkinElmer) and the Mouse Metabolic Magnetic Bead Panel (Millipore)