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Each has its own timing pattern: Constipation tends to worsen gradually over the first 48 to 72 hours after injection, then slowly improve as drug levels decrease

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In other words, if a pharmaceutical company thinks it can make a prescription drug out of a popular supplement ingredient, it can file a new drug application for a patented form of that ingredient, and the FDA will put out a letter stating that further sales of that ingredient in supplement form are prohibited

More stable ingredient methods are also better for insurance and liability reasons

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