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A growing array of treatment modalities and new entrants are crowding the market, with biotech companies promoting next-generation GLP-1 candidates alongside established pharmaceutical players

Performance testing: Standardized exercise tests like time trials, max heart rate sustainable pace, or strength benchmarks document performance changes objectively

doi: 10.1038/nrdp.2016.57 159 JohamAEPiltonenTLujanMEKiconcoSTayCT

Adipose tissue also directly produces pro-inflammatory cytokines such as IL-6, TNF, and IL-8

The other two-thirds appears to come from direct effects on inflammation, vascular function, and blood pressure