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Description

Evaluation of carnitinean antagonist of thyroid hormone

Both are contraindicated in patients with active malignancy, recent cancer history, or severe cardiovascular disease

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These effects depend on integrin alpha-1 and beta-1 pathway activation

The biological activity can be assessed using a colorimetric bioassay consisting of the engineered cell line HEK-Blue GLP-1 expressing the GLP-1R together with a CREB-inducible SEAP reporter gene (see figure)