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As HFpEF began to manifest at 10 to 13 weeks and progressed until rats were sacrificed at 20 weeks of age, alpha-diversity, a measure of species diversity within sample, consistently remained significantly lower

in: PubMed | Google Scholar | 1 Department of Medicine, University of Verona, and Azienda Ospedaliera Universitaria Verona, Policlinico GB Rossi, Verona, Italy

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PTX treatment had no effect on the maximum calcium mobilization in response to MDL29,951 (972.4% of the maximum response of the vehicle treatment condition) but was accompanied by a 3-fold shift in the EC 50 of MDL29,951 from 440 nM (pEC 50 = 6.340.06) for vehicle treated to 1300 nM (pEC 50 = 5.890.03) for PTX treated cells, suggesting a role for Gi/o-mediated signaling (Figure 2C)