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It is derived from the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), which is a natural fragment of IgG immunoglobulin

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However, there are disputes about the relevant applicability of this evidence [18, 19], particularly considering the low survival rate of bone marrow stromal cells transplanted into the contused adult rat spinal cord [20, 21] and the need to completely fill the lesion site with neural stem cells [22]

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