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Its analogue peptide p18 (WXEAAYQRFL), proteolytically stable in human serum, binds to keratin 1 receptor (Shahin et al., 2013), and DOX loaded P18-PEtOx-dioleoyl phosphatidyl ethanolamine (DOPE) nanoliposomes designed for targeting AU565 cells elicited a strong antitumor response compared to free DOX (Bolat et al., 2021) (Figure 2)

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We hope this gives some insight into the problematic nature of pinpointing cause and effect within the constraints of such a complex environment